Benzodiazepine receptor binding in Huntington's disease: [11C]Flumazenil uptake measured using positron emission tomography
Identifieur interne : 001172 ( Istex/Checkpoint ); précédent : 001171; suivant : 001173Benzodiazepine receptor binding in Huntington's disease: [11C]Flumazenil uptake measured using positron emission tomography
Auteurs : Gabriella Künig [Suisse] ; Klaus L. Leenders [Suisse, Pays-Bas] ; Rosario Sanchez-Pernaute [Espagne] ; Angelo Antonini [Italie] ; Peter Vontobel [Suisse] ; Aalt Verhagen [Suisse] ; Ilonka Günther [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 2000-05.
Abstract
We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation. We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation. Ann Neurol 2000;47:644–648
Url:
DOI: 10.1002/1531-8249(200005)47:5<644::AID-ANA13>3.0.CO;2-C
Affiliations:
- Espagne, France, Italie, Pays-Bas, Suisse
- Canton de Zurich, Communauté de Madrid, Groningue (province), Lombardie
- Groningue, Madrid, Milan, Orsay, Zurich
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We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation. We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation. 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